In Mike Tyson's Punch-Out!!, King Hippo is the most unique character of the World Video Boxing Association, being the only character who has no palette swap. His defense is impenetrable until he opens his mouth. When his mouth is hit, Hippo reveals his one weakness: his overly large trunks start falling down, and he has to keep pulling them up whilst trying to fend off Little Mac's body blows. Uniquely, King Hippo has no opportunities to get stars and therefore can only be hit by normal punches. However, once Little Mac floors King Hippo, he does not get up.