Journalist Eddie Brock (Tom Hardy) begins investigating the Vida Foundation, led by scientist Carlton Drake (Riz Ahmed). Discovering that they are conducting experiments on humans and alien life forms, he will do his best to expose such excesses. Task that will affect him professionally and personally with his girlfriend Anne (Michelle Williams). So, trying to obtain evidence of a strange independent organism called a symbiote, one of the creatures escapes, taking Eddie as a host. A strange and powerful being that he sometimes tries to control, but he will also let himself go.