The Callisto Protocol is a 2022 survival horror action video game developed by Striking Distance Studios and published by Krafton. It was directed by Glen Schofield, who had previously co-created the Dead Space series. The game's story follows Jacob Lee (Josh Duhamel) who is sent to a prison facility set on the Jovian moon Callisto fighting against infected prisoners with an unknown disease while uncovering dark secrets of the facility. Gameplay has players exploring a series of levels, garnering resources while fighting off infected prisoners.

Development of the game began with the formation of Striking Distance Studios in June 2019. Originally developed as a game set in the PUBG: Battlegrounds universe, it later evolved into an original intellectual property.

The game was released for PlayStation 4, PlayStation 5, Windows, Xbox One, and Xbox Series X/S on December 2, 2022. It received mixed reviews.