Straizo is, along with Dire and Will Anthonio Zeppeli, one of Tonpetty's followers. During the events of Phantom Blood, Straizo accompanies Tonpetty after they have received a letter from Will asking for help in destroying the Stone Mask, but they arrive too late to prevent his death. He helps Jonathan in the fight against Dio Brando and his minions, easily defeating Page, Jones, Plant, and Bornnam to protect Poco and his sister. During the fight, Straizo witnesses the power of the Vampires firsthand. He later appears to wish Jonathan and Erina a good honeymoon.